The Oral Microbiome Opportunity and Identifying the Biomarkers for Early Stage Parkinson’s Disease
Date & Time
Thursday, June 4, 2020, 9:25 AM - 9:50 AM
Frank Middleton

• Using shotgun metatranscriptomics and metagenomics to map taxa of healthy vs early stage Parkinson’s patients revealed 40 distinct taxa with altered abundance, including clusters of specific Lactobacilli.

• The approach also revealed shifts in functional transcriptional networks of oral bacteria and the human host.

• This approach thus facilitates identification of biomarkers that may help improve the accuracy of Parkinson’s diagnosis, and indicate potential therapeutic opportunities.

• Current work is expanding the human studies and using in vitro and in vivo mouse models to investigate the possible manipulation of the microbiome to improve Parkinson’s related symptoms.

Session Type
Virtual Session Link
Session Themes
On Demand